Tuesday, February 18, 2020

low cost portable MRI

FDA Clears 'World's First' Portable, Low-Cost MRI Following Positive Clinical Research (healthimaging.com)25

Magnetic resonance imaging is no longer confined to radiology departments. The U.S. Food and Drug Administration announced this month that it has provided clearance to the "world's first" bedside MRI system, according to an announcement. From a report:Hyperfine said it will begin shipping its portable, low-field modalities this summer. It's 510(k) clearance falls on the same day that Yale researchers reported the device can accurately and safely image patient's brains for stroke. Those preliminary results are set to be presented next week at the American Stroke Association's International conference in Los Angeles, the group announced. "We've flipped the concept from having to get patients to the MRI to bringing the MRI to the patients," said Kevin Sheth, MD, senior author and a chief physician at Yale School of Medicine. "This early work suggests our approach is safe and viable in a complex clinical care environment."

The study included 85 stroke patients who underwent bedside MRI within seven days of experiencing symptoms. A majority of individuals completed the exam, which took an average of 30 minutes. Six experienced claustrophobia and a few couldn't fit into the machine, but there were no adverse events. According to Connecticut-based Hyperfine, their machine will cost $50,000, which is 20-times cheaper than traditional systems, runs on 35-times less power and weights 10 times less than normal 1.5T MRI machines.

Monday, February 10, 2020

Facebook workplace Kintaba

Facebook Workplace Co-Founder Launches Downtime Fire Alarm Kintaba (techcrunch.com)9

Facebook Workplace co-founder John Egan is launching Kintaba, "a more holistic solution to incident response," reports TechCrunch. From the report:Code failure downtimes, server outages and hack attacks plague engineering teams. Yet the tools for waking up the right employees, assembling a team to fix the problem and doing a post-mortem to assess how to prevent it from happening again can be as chaotic as the crisis itself. Text messages, Slack channels, task managers and Google Docs aren't sufficient for actually learning from mistakes. Alerting systems like PagerDuty focus on the rapid response, but not the educational process in the aftermath. The Kintaba team experienced these pains firsthand while working at Facebook after Egan and Zac Morris' Y Combinator-backed data transfer startup Caffeinated Mind was acqui-hired in 2012. Years later, when they tried to build a blockchain startup and the whole stack was constantly in flames, they longed for a better incident alert tool. So they built one themselves and named it after the Japanese art of Kintsugi, where gold is used to fill in cracked pottery, "which teaches us to embrace the imperfect and to value the repaired," Egan says.

With today's launch, Kintaba offers a clear dashboard where everyone in the company can see what major problems have cropped up, plus who's responding and how. Kintaba's live activity log and collaboration space for responders let them debate and analyze their mitigation moves. It integrates with Slack, and lets team members subscribe to different levels of alerts or search through issues with categorized hashtags. As the fire gets contained, Kintaba provides a rich text editor connected to its dashboard for quickly constructing a post-mortem of what went wrong, why, what fixes were tried, what worked and how to safeguard systems for the future. Its automated scheduling assistant helps teams plan meetings to internalize the post-mortem.

Thursday, February 6, 2020

Cancer map

More than a thousand scientists have built the most detailed picture of cancer ever in a landmark study. They said cancer was like a 100,000-piece jigsaw, and that until today, 99% of the pieces were missing. Their studies, published in the journal Nature, provide an almost complete picture of all cancers. They could allow treatment to be tailored to each patient's unique tumor, or develop ways of finding cancer earlier. The Pan-Cancer Analysis of Whole Genomes Consortium analyzed the whole genetic code of 2,658 cancers.

The project found people's cancers contain, on average, between four and five fundamental mutations that drive a cancer's growth. These are potential weak-spots that can be exploited with treatments that attack these "driver mutations." However, 5% of cancers appear to have no driver mutations at all, showing there is still more work to do. Scientists also developed a way of "carbon dating" mutations. They showed that more than a fifth of them occurred years or even decades before a cancer is found. "We've developed the first timelines of genetic mutations across the spectrum of cancer types," said Dr Peter Van Loo from the Francis Crick Institute. He added: "Unlocking these patterns means it should now be possible to develop new diagnostic tests, that pick up signs of cancer much earlier."


https://www.nature.com/collections/afdejfafdb/