Thursday, June 22, 2017

punk hip hop

See also Masked Gorilla for documentation of this genre

I've been noticing this around Atlanta - black kids wearing a punk meets high fashion combo, and t-shirts with 80s and 90s era metal bands. The article mentions anime as an influence.

 “When I first met all these kids, these kids looked 10 percent punk,” said Jimmy Duval, one of the scene’s key producers. “As the sound got bigger, their image got bigger with the sound.”

Listed in this article:


Gucci Gang

Lil Pump

Lil Peep

Mr. Gengo


Trippie Redd

Matt Ox

Chief Keef


“Back in the day, it was probably more 85-15,” he said, describing how he split his attention between image and music. “As of now, it’s more like 60 percent music, 40 percent image.”



Mr. Duval (beats)


Raider Klan

Denzel Curry

Yung Simmie

Fat Nick


Lil Uzi Vert

Young Thug

Chief Keef

Sunday, June 18, 2017

PC build equivalent to X Box One X

Xbox One X PC Build: Can you do it for $500?

Creating the PC equivalent of the $500 Xbox One X is trickier than you might guess.

microsoft xbox one x blowout parts e3 2017
Credit: Adam Patrick Murray


Updated June 16, 2017: We've revised our “upgraded” build to address our original motherboard’s incompatibility with 4K UHD HDR Blu-Ray playback.
Microsoft’s Xbox One X presents an interesting challenge for PC builders. Sure, if you want raw power, nothing beats the PC. But can you put together an Xbox One X equivalent for $500?
At that price point (and outside of that golden window of Black Friday sales and stellar combo/bundle deals on PC components), you're pushing the limits of what’s possible, particularly if you want to completely replicate the same experience Microsoft is promising hardcore console fans. Given today’s high RAM prices, the low availability of certain GPUs, and the dearth of 4K UHD drives, the results don’t come out cleanly in favor of a DIY PC.

Build #1: A basic 4K/30-fps gaming PC

To start, we’ll walk through a baseline build, which makes a few sacrifices but should still perform at 4K/30 fps.

CPUAMD FX-8300 (3.3GHz, 8-core)
MotherboardASRock 970 Pro3 R2.0 ATX AM3+[3][4]$45
RAMPatriot Signature 8GB DDR3/1600 (1x8GB)$47
Graphics cardGigabyte Radeon RX 580 8GB Gaming 8G[5]$266
StorageWestern Digital 1TB Caviar Blue 3.5” 7200RPM HDD$50
Optical DriveLG UH12NS40 Blu-Ray drive$43
PSUThermaltake SMART 550W 80+ Bronze[6]$35
CaseThermaltake Versa H21 ATX Mid Tower$34
OSWindows 10 OEM license$32
ShippingMotherboard ($1), Graphics Card ($9)$10
Build notes
  1. Prices current as of June 15, 2017.
  2. Retailers chosen with shipping costs in mind—and the assumption most people have an Amazon Prime account.
  3. Cheap AM3+ motherboards like the ASRock 970 Pro R2.0 lack on-board Wi-Fi, so if you want wireless connectivity, prepare to shell out for either a Wi-Fi adapter or a better motherboard. 
  4. The price for this ASRock motherboard is after a $20 mail-in rebate.
  5. See the Build Summary section for notes on availability.
  6. This price is after $20 mail-in rebate.

Build breakdown

When comparing our build to the Xbox One X piece by piece, each platform’s advantages are clear. Our PC has more flexibility and muscle, while the Xbox One X is both highly compact and set in stone.
For the Xbox One X’s CPU, GPU, and memory, Microsoft chose a custom AMD APU that features eight 2.3GHz custom x86 cores, 40 Radeon compute units running at 1,172MHz, and 12GB of GDDR5 memory. AMD doesn’t have an equivalent APU available for DIY build purposes, so I chose to walk the line between the Xbox One X’s specs and recommended specs for a smooth PC gaming experience. In our build is the eight-core 3.3GHz AMD FX-8300, 8GB of DDR3/1600 RAM, and an 8GB Radeon RX 580. (My GPU choice does have one catch, which I’ve noted in the Build Summary below.)

Brad Chacos/IDG

This configuration nets you a (faster) eight-core CPU, enough RAM to avoid bottlenecks in system performance, and a GPU capable of 4K gaming at a minimum of 30 fps on Medium settings. However, some Xbox One X games may end up running more smoothly or with better visual fidelity on console than on this homebrew 4K machine. Unlike with the PC, developers can fine-tune their games for Microsoft’s console through a low-level API.
For storage, Microsoft hasn’t yet shared details on drive speed, type, or interface. All we currently know is what Digital Foundry revealed in its April 2017 preview: The Xbox One X will have a “1TB hard drive with a 50 percent increase in bandwidth.”

Without knowing how Microsoft arrived at that 50 percent figure, we could spend a lot of time speculating on what it means. (Do they mean a shift from SATA II/3Gbps to SATA III/6Gbps? Use of a solid-state hybrid drive? A larger cache?) Instead, I chose to keep this exercise simple and selected a SATA III 7200rpm Western Digital hard disk drive. While it’s possible that the Xbox One X's $500 price tag includes a SSHD, like in its now-discontinued Xbox One Elite model, that raises the price of this build without explicit cause.

xbox one x hard drive
Adam Patrick Murray/IDG
The Xbox One X hard drive, as shown at Microsoft’s Xbox showcase at E3 2017.

The final pieces of this build are straightforward. In fact, you can use any reputable 500W power supply (the minimum you’ll need for this build), ATX case, and Blu-Ray drive—the ones listed in our build were chosen for how cheap they were at the time of publication.
Speaking of that Blu-Ray drive, it’s a far step down from the Xbox One X’s 4K UHD Blu-Ray drive. To stay even remotely near a final total of $500, you have to ditch support for playback of 4K UHD discs. So that means you can’t play your collection of 4K UHD movies in HDR on a compatible TV, if you already own one.
As for the operating system, we can’t go as cheap as the Xbox One X’s included variant of Windows 10, but we can get a W10 Home license at a heavy discount. How? By using a trick that Brad Chacos has mentioned to our staff for a while now: Buying a product key through Kinguin. It works, but be sure to get the Buyer Protection—the site functions like an eBay for software, and that insurance will protect you from shady sellers.

Build summary

As mentioned above, we wanted to replicate both the functionality and the price of the Xbox One X as closely as possible. You can’t do an exact 1:1 duplicate, thanks to a mix of Microsoft’s custom hardware design and slow release of specs, but this build is a fairly decent compromise between Xbox One X’s main features and the cost of PC components. This rig should play games in 4K at a minimum of 30 fps on a Medium graphics setting, support HDR, and play optical discs.
However, it’s more expensive than an Xbox One X by $152 (or more, if you’re bad about filing mail-in rebates). It lacks support for 4K UHD Blu-Ray discs. It uses a GPU that’s extremely difficult to find right now, so currently you’d have to pay more for a used RX 580 or buy a graphics card with less memory (Nvidia’s 6GB GTX 1060 instead of a 8GB Radeon RX 580). It doesn’t have built-in Wi-Fi support. And it’s not nearly as compact or small.

Build #2: The upgraded 4K/30-fps gaming PC

Our second build swaps out the standard Blu-Ray drive for a 4K UHD Blu-Ray drive—and changes the CPU and motherboard configuration as well.
CPUIntel Core i5-7400 (3.0GHz, 4-Core)$187
MotherboardASRock Fatal1ty Z270 GAMING-ITX/AC[3]$149
RAMCrucial 8GB DDR4/2133 (1X8GB)$55
Graphics cardGigabyte Radeon RX 580 8GB Gaming 8G[4]$266
StorageWestern Digital 1TB Caviar Blue 3.5" 7200RPM HDD$50
Optical DrivePioneer BDR-211UBK 4K UHD Blu-Ray drive$130
PSUThermaltake SMART 550W 80+ Bronze[5]$35
CaseRosewill Dual Fan Micro ATX Mini Tower$28
OSWindows 10 OEM license$32
ShippingOptical Drive ($1), Motherboard ($2), Graphics Card ($9)$12
Build Notes
  1. Prices current as of June 15, 2017.
  2. Retailers chosen with shipping costs in mind—and the assumption most people have an Amazon Prime account.
  3. The price for this ASRock motherboard is after $10 mail-in rebate.
  4. See the Build Summary section for notes on availability.
  5. This price is after $20 mail-in rebate.

Build breakdown

For the most part, this build shares the same approach as our first one. The key difference is the addition of Pioneer’s 4K UHD Blu-Ray drive to closely match what the Xbox One X has.
That 4K UHD Blu-Ray drive makes this build quite a bit more expensive than an Xbox One X. The BDR-211UBK itself is $130, and its highly restrictive system requirements also require a more expensive CPU and motherboard. The cheapest compatible processor is a $187 Kaby Lake Core i5-7400, and since only a few motherboards support the draconian DRM specifications for 4K UHD Blu-ray disc playback, the lowest-cost option is $149.

pioneer 4K UHD Blu-Ray drive

For the moment, you can’t get around this painful jump in cost. Pioneer has the only options for a 4K UHD Blu-Ray drive currently—and this one we’ve picked is the cheaper of the two.

Build summary

This upgraded rig nails the Xbox One X’s main features: It should run games in 4K at a minimum of 30 fps on a Medium graphics setting, support HDR, and play 4K UHD optical discs.
However, like the first build in this article, it has its downsides. First of all, if you build this PC at this very moment, you’ll have a rough time finding an RX 580. You’ll end up paying more or purchasing a GTX 1060 (which has less memory) instead.
It’s also much more expensive than the Xbox One X. At $944, you could buy the Xbox One X almost twice over.

Final thoughts

For the moment, Microsoft’s created a machine that the DIY PC crowd can’t currently match—not when you try to copy both its feature set and cost at the same time, at least. The 4K UHD Blu-Ray disc drive really throws a wrench into this build challenge, and even without it, the Xbox One X holds its own. This situation might be a first, given how often PC gamers tout benefits that console fans miss out on.

xbox one x @ microsoft e3 showcase
Adam Patrick Murray/IDG

Still, it’s not a complete victory for the Xbox One X. PC gaming doesn’t require an optical drive, after all, so you can enjoy 4K gaming, 4K video content, and HDR through digital downloads. (The RX 580 will handle all that just fine.) That already drops the cost of the cheaper build we priced out.
Beyond that, these builds could change the closer we get to the Xbox One X’s launch date. When AMD’s Ryzen 3 line launches, it might offer even better CPU performance for the same price as the FX-8300. Prices might come down for RAM and Pioneer’s 4K UHD Blu-Ray drive. Availability for the RX 580 may increase again. And of course, the holiday shopping season should yield some sweet deals on at least some of these build components. By November 7th, the Xbox One X may be far easier to reproduce as a punchy $500 PC.

Sunday, June 11, 2017

Cancer drug

Adrienne Skinner of Larchmont, N.Y., had an extraordinarily rare and deadly cancer with no standard treatment. She started taking Keytruda in 2014 and her tumor is gone. CreditWhitten Sabbatini for The New York Times
The 86 cancer patients were a disparate group, with tumors of the pancreas, prostate, uterus or bone. One woman had a cancer so rare there were no tested treatments. She was told to get her affairs in order.
Still, these patients had a few things in common. All had advanced disease that had resisted every standard treatment.
All carried genetic mutations that disrupted the ability of cells to fix damaged DNA. And all were enrolled in a trial of a drug that helps the immune system attack tumors.
The results, published on Thursday in the journal Science, are so striking that the Food and Drug Administration already has approved the drug, pembrolizumab, brand name Keytruda, for patients whose cancers arise from the same genetic abnormality.
Continue reading the main story
“This is absolutely brilliant,” said Dr. José Baselga, physician in chief at Memorial Sloan Kettering Cancer Center in New York, which has just hired the study’s lead investigator, Dr. Luis A. Diaz Jr.
After taking pembrolizumab, 66 patients had their tumors shrink substantially and stabilize, instead of continuing to grow. Among them were 18 patients whose tumors vanished and have not returned.
There was no control group, which meant the results had to be absolutely compelling to be convincing. The study started in 2013 and is funded by philanthropies; the drugmaker’s only role was to supply the drug. The study is continuing.
The drug, made by Merck, is already on the market for select patients with a few types of advanced lung, melanoma and bladder tumors. It is expensive, costing $156,000 a year.
A test for the mutations targeted by the drug is already available, too, for $300 to $600.
Just 4 percent of cancer patients have the type of genetic aberration susceptible to pembrolizumab. But that adds up to a lot of patients: as many as 60,000 each year in the United States alone, the study’s investigators estimated.
Clinicians have long been accustomed to classifying cancers by their location in the body — patients are diagnosed with lung cancer, for example, or brain cancer.
Yet researchers have been saying for years that what matters was the genetic mutation causing the tumors. At first, they were certain they would be able to cure cancers with drugs that zeroed in on the mutations, wherever the tumors were lodged.
But cancers were more complicated than that, said Dr. Drew M. Pardoll, director of the Johns Hopkins Bloomberg-Kimmel Institute and an author of the new paper.
A mutation that appeared in half of all melanomas, for example, turned out to be rare in other cancers. And even when scientists pinpointed that mutation in 10 percent of colon cancers, the drug that worked for melanoma patients did not work for other cancer patients.
“It was a great dream,” Dr. Pardoll sighed.
The new study was based on a different idea. The immune system can recognize cancer cells as foreign and destroy them. But tumors deflect the attack by shielding proteins on their surface, making them invisible to the immune system.
Pembroluzimab is a new type of immunotherapy drug known as a PD-1 blocker, which unmasks the cancer cells so that the immune system can find and destroy them.
The drug is the happy result of a failed trial. A nearly identical drug, nivolumab, was given to 33 colon cancer patients, and just one showed any response — but his cancer vanished altogether.
What was special about that one patient? Dr. Diaz, a geneticist at Johns Hopkins until now, and lead author of the new study, found the answer: a genetic mutation that prevented the tumor from repairing DNA damage.
As a result, the man’s cancer cells contained a plethora of mutated genes, which produced thousands of strange-looking proteins on the surfaces of the cells. Once the tumor’s cloaking mechanism was short-circuited by the drug, the man’s immune system had no trouble targeting the foreign proteins on the cancer cells.
That led to the idea for the Dr. Diaz’s new study. He and his colleagues sought patients whose tumors had the same genetic defect, which can arise in any of four genes in a pathway that repairs damaged DNA. They gave these patients a PD-1 blocker and were surprised by the results.
The drug’s effects have been so durable that the investigators do not know how long the results should be expected to persist or how long these patients might expect to survive. That kind of result, Dr. Baselga said, “is insane.”
One patient in the study, Adrienne Skinner, 60, of Larchmont, N.Y., had an extraordinarily rare and deadly cancer, ampullary cancer, that arises at the end of the bile duct. There is no standard treatment, and the prognosis is dire.
Her doctors scheduled her for a drastic surgery that removes part of the pancreas, part of the small intestine, and the gall bladder. But her surgeon canceled the operation when he discovered her cancer had invaded her liver.
She tried chemotherapy instead — six months of one kind, then six months of another. Neither worked.
Then she qualified for Dr. Diaz’s clinical trial at Johns Hopkins. On April 15, 2014, Ms. Skinner had her first dose of the drug.
In July, her doctor inserted an endoscope for another biopsy. He turned to Ms. Skinner and said, “If someone hadn’t told me you have ampullary cancer, I would not have known.” The tumor was gone.
The trial involved giving patients the drug for two years, so Ms. Skinner continued to take the drug as a sort of insurance. Last year, she stopped, and her cancer has not returned.
“In effect, I was cured within months,” she said. “I have a great life.”
But even this promising trial has left a thread dangling: Why didn’t all of the patients respond?
There is now a fervid search for the answer. “Multiple labs are looking like crazy,” Dr. Balsega said.