Thursday, March 19, 2020

No business like COVID-ness


Read Part 2

Yet another polarizing social issue, Americans don't know whether to shit their pants or roll their eyes. 


And now we're rolling out an economic stimulus. So, China just effectively sold us $1 trillion pandemic. I mean, who do you think we're borrowing the trillion from? But we should have buyers regret, because we agreed to pay for it. Nothing sells like liability insurance. And that's what all this political correctness is really about, it's certainly not about values, justice or genuine compassion. The counterpoint to liability is opportunity. That's the yin to our yang.

I suppose I should come up with a bumper sticker or a T-shirt idea. 

All viruses matter. The coronavirus ate my homework. I would pray about the coronavirus but according to CDC guidelines two or more cannot gather. At least for two weeks. 

For the generally healthy, catching the virus means eight hours of high fever and then you can get on with your life. But all the emphasis in the media is on it being so contagious and how fast it’s spreading, how it’s going to get you. 

How long are they going to keep this going? As long as people are unable to go anywhere, the media can enjoy eyeballs on televisions, monitors, tablets and phones.


If it's really about conscientiousness, when will it ever really be okay? It's just not sustainable. 

There are some who will talk about trying to protect old people and flattening the curve, and that’s fine, but it’s not worth shutting down the entire economy, killing businesses and ruining lives. And come on, that’s really what this is about. They’ve never handled any other virus this way.

And all in time for the election.

You know who likes to wear masks? Millennials and communists. People who like having rules shoved way up their ass so they feel safe. Next up, who's gonna start shaming and peddling another F'd up government health care plan in the name of rescuing us from COVID?

COVID hysteria harkens back to all the saber-rattling following 911, everyone glued to the TV, watching the invasion of Afghanistan to a soundtrack of symphonic music. Orange alerts and government guidelines recommending duct tape, and all the fashionably non-intrusive black, square W stickers on all the giant gas-guzzling SUVs as we tear into the Middle East. The Toyota Sequoia (2000-2020), the mightiest tree in the forest!

During the immediate aftermath period, anyone who dared question history or whether the terrorists attacked because they 'hate our freedom' was marked as traitorous. After a few months, it was a clear social split and then anyone confused for being on the 'other side' of a 'discussion' became othered as an enemy. I recall an argument around Thanksgiving with one cocky jackass...ummm...my brother-in-law...who bragged how we'd be in and out in three weeks. Fast forward 19 years later, and our administration is just now teasing the idea of bringing our troops home. A lasting military and social quagmire.

Let's not forget, around this same time is when digital killed both the music industry and print. Enter the rise of social media and the death of newspapers, so marks a serious turn in our cultural demise. News and music begin to blur into anything for ratings. Anything other than news or music. And lots of ass. So, retro goes way vogue, mainstream movies and music subsist on regurgitated remakes and that sets the tone and trajectory for the new indie hipsters. And by 2009, we are in a recession. Not long thereafter, all the indie hipsters are playing in retro cover and tribute bands. And that's hip. So much for originality. Long live ass!

Fast forward 20 years or so later, noone remembers how we got here, and Amazon owns the Washington Post as it silently spreads its tendrils across the country like the new Roman Empire.

Regardless of alignment, people suck the tit of media like a cranky baby. So, politics are a fairly predictable puppet show, and the pendulum swings harder and further each way. Pick a team and buckle in for the next episode of Divide and Conquer.

Each President since JFK is more grotesque than the next. It's like watching Elvis, Liberace and Michael Jackson walk into a bar at the start of their careers, all wearing plain suits, and they all end up staggering out as some twisted caricature of themselves wearing capes, giant jewel encrusted glasses, and...looking like Diana Ross. That's entertainment.
But, back to our current crisis and parallel media circus. 

I asked a Chinese friend of mine why the Asians all wear masks. Is it because they feel suspect amongst the xenophobic Americans, or because they actually believe they need to? He said it’s because the Chinese government makes them do it so they are willing to do whatever they need to help. I guess that includes drowning their baby girls in a lake, whatever it takes for the common good.


But as for Americans, no matter how far removed or irrelevant, everyone has something to say. And something to sell. I haven't seen such a frothing swarm of zombie necrophiliacs pile on since Neil Peart died and everybody made their shitty YouTube tribute video. And an email from every corner of existence, anyone who thinks you are their audience, they can find an excuse to draw some attention to themselves surfing the corona wave.

All this nonsense about social distancing. Please, I don’t even like to wear condoms, good luck getting me to wear a mask.

One of the best Saturday nights of my life, I figured the usual crowd would be thinned at Johnny’s Hideaway - aka The Waiting Room of the Damned. Best looking crowd I’ve ever seen there, and just as suspected, plenty of space on the dance floor because all the crypt keepers and idiots stayed home. If this is what it takes to have decent looking women and space at Johnny's, we need to have a pandemic more often. In fact, a friend of mine called me up just before I left and said they were having a coronavirus party.

Right now, round trip tickets from Atlanta to California are $100, $75 to Miami, and the beaches of Spring Break are still packed. 

Look, this is not the plague, this is just a damn flu. You might even say corona has viral privilege. I mean, it's become a most undeserving rock star of a virus, overnight. It's cringeworthy, like COVID is performing a panic cover on American Idol, and The Black Death is squirming uncomfortably amongst the panel of judges, squished appropriately up against a very ghoulish Steven Tyler, and scoffing resentfully '...hell, back in my day...' This is how U2 must feel watching Cold Play.

Surely, the Corona Virus is destined to be Time's Virus of the Year. 


If we are so damn capable of putting emergency medical resources to work, why didn’t we do this with HIV or even herpes. Talk about social distancing, and here we are putting emergency resources towards what for most amounts to an 8-hour fever? We could’ve saved Michael Douglas from throat cancer, or Farrah Faucett from her anal warts. 

LA Fitness is closed for two weeks, then my apartment gym closed. So, I thought to ride over to the river park. As I made my way, I noticed the sidewalks were teaming with walkers and joggers. It’s almost April and people have spring fever, there’s no way in hell this virus is going to shut down the American lifestyle. 

Do you think people who drive SUVs give a fuck about the environment or other people? They’re sure as hell not putting on a mask and doing any social distancing. 

If you’re a big enough of an asshole to post a gym selfie or a sexy yoga pose on IG, you’re sure as hell not missing your opportunity to show off your beach body and new tattooey somewhere when all the pools are closed. Or to show your ass crack if that’s how you like to wear your pants. 


Whatever your demographic, clique or lifestyle, Americans enjoy their freedom. Even if they burn the flag or take a knee at a football game. That’s their idea of freedom of expression, whether they are letting their freak flag fly or just basking in their moment to shock and draw attention. If you want to slap on a wig and chop your dick off and then go into a woman’s restroom, an entire industry will boycott the state if everyone doesn’t happily go along with it. So, what’s so special about this situation? 

Liability is Americas kryptonite. One sniff and we way overcompensate and overcorrect, with lots of posturing and pleasantries. In exchange, everyone jumps on the virtue signaling bandwagon as a cosmetic cover-up, but it’s a marketing opportunity, even if it’s as minute as getting a like on Facebook. 

Athens, GA now has a 9 o’clock curfew to prevent social gathering. It’s a University town, so it's all about liability. That beer can wait. Sucks to be a local.

Hopefully Tom Hanks and his wife pull through and then nobody gives a shit anymore. If this is part of the next round of elaborate political hijinks designed to sink Trump's 2020 re-election by kicking over his economic sandcastle, it's yet another colossal waste. And for what, Joe Biden? The virus will probably take Joe out anyway. 

And the ebbing and flowing rumor of the next recession has been so tantalizing, maybe it would have turned that sandcastle to mush anyway, but apparently, we needed a bigger rumor, we needed it sooner. What? This is no rumor, it's a pandemic! Like police shootings. Gather the mobs and burn our cities to the ground! No, scatter the mobs and shutter your windows and doors. It's the apocalypse!


If Hanks kicks the bucket, he'll miss out on being Oprah’s Vice President in 2024. So, hurry up with that malaria medicine, click those ruby slippers three times, or whatever it is that they're furiously working, all the nebulous solutions they dangle to keep us in indefinite suspense. They can try to convince us there's no place like home, but we know better. Even with 5G.

From the latest article I found on Tom Hanks, sounds like he's already in training for VP, 
saying the symptoms were “much the same … no fever but the blahs. Folding the laundry and doing the dishes leads to a nap on the couch.”



Wednesday, March 11, 2020

HIV Cured

Second Person Cured of HIV Is Still Free of Active Virus Two Years On (cnn.com)39

An anonymous reader quotes a report from CNN:The second person ever to be cured of HIV is still free of active virus more than two years on, a study published by medical journal The Lancet HIV revealed on Tuesday. Two and a half years ago, Adam Castillejo -- previously identified as the "London patient" -- finished HIV antiretroviral therapy. He underwent a stem cell transplant to treat lymphoma and his donor carried a mutation known as CCR5-delta 32, which made him resistant to HIV. Researchers said that in treating his lymphoma, they believe Castillejo, now 40, was cured of HIV.

"Our findings show that the success of stem cell transplantation as a cure for HIV, first reported nine years ago in the Berlin patient, can be replicated," said Ravindra Gupta, lead author of the study and a professor in University of Cambridge's clinical microbiology department. Unlike the Berlin patient -- identified later as Timothy Ray Brown -- Castillejo underwent only one stem-cell transplantation instead of two and did not have radiotherapy to his entire body as part of his treatment. Castillejo represents a step toward a less intensive treatment approach, the authors said. Still, given the invasive nature of the experimental treatment, the authors caution its widespread use.

Wednesday, March 4, 2020

digital art frames

https://www.niio.com/

$800-1800
https://www.samsung.com/us/televisions-home-theater/tvs/the-frame/highlights/

$550 - 660
https://www.nimbusframe.com/pricing/

honeywell quantum computing

https://www.engadget.com/2020/03/03/honeywell-quantum-computer/

Honeywell says it built the world's most powerful quantum computer

It will share more details on it sometime in the next three months.
Igor Bonifacic@igorbonifacic
23h ago

When it comes to quantum computers, we tend to think of companies like Google and IBM as the big players in the field, but there could soon be more competition in the space. Honeywell says sometime in the next three months it will unveil a quantum computer that is at least twice as powerful as any current device.

Breaking down that claim requires some context. As Protocol points out, most companies talk about qubits when they speak to the capabilities of their machines. For instance, Sycamore, the computer Google claimed last year achieved quantum supremacy, had 53 qubits. Honeywell is instead using a metric called quantum volume to talk up the capabilities of its machine. IBM coined the term, and here's how it defines it:

"Quantum Volume takes into account the number of qubits, connectivity, and gate and measurement errors. Material improvements to underlying physical hardware, such as increases in coherence times, reduction of device crosstalk, and software circuit compiler efficiency, can point to measurable progress in Quantum Volume, as long as all improvements happen at a similar pace."

The point here is that quantum volume attempts to measure the performance of a computer by taking a holistic view of its different parts. Raw qubits are important in the calculation, but so is how they interact with one another. For instance, the lower the error rate those qubits generate, the better the score. Ultimately, however, the larger the quantum volume value, the more complex problems the computer can solve.

Honeywell claims its upcoming computer will have a quantum volume of at least 64. To put that number in perspective, IBM recently announced a 28-qubit computer it built had a quantum volume of 32. The company was able to achieve this feat in part to thanks to a breakthrough it made in 2015 when it developed a technology that uses lasers to trap electrically charged atoms in a superpositioned state.

As exciting as Honeywell's achievement is, it's probably best not to get too excited until the company properly details the computer. Last year, Google generated conflicting amounts of hype and controversy when it announced that it had achieved quantum supremacy. IBM, in particular, called the company's claims "indefensible" based on the fact Google built Sycamore to solve one specific equation.

That said, it appears most other companies are at least optimistic about what Honeywell has managed to do. For instance, IBM's Research arm told Protocol, "Honeywell's paper shows exciting new progress in programmable trapped-ion quantum systems." The company has also gained the Microsoft seal of approval, with the two announcing a partnership that will give Azure clients access to Honeywell's quantum computer.

CRISPR first

https://www.npr.org/sections/health-shots/2020/03/04/811461486/in-a-1st-scientists-use-revolutionary-gene-editing-tool-to-edit-inside-a-patient

In A 1st, Scientists Use Revolutionary Gene-Editing Tool To Edit Inside A Patient

Scientists at the Casey Eye Institute, in Portland, Ore., have have injected a harmless virus containing CRISPR gene-editing instructions inside the retinal cells of a patient with a rare form of genetic blindness.
KTSDesign/Getty Images/Science Photo Library
For the first time, scientists have used the gene-editing technique CRISPR to try to edit a gene while the DNA is still inside a person's body.
The groundbreaking procedure involved injecting the microscopic gene-editing tool into the eye of a patient blinded by a rare genetic disorder, in hopes of enabling the volunteer to see. They hope to know within weeks whether the approach is working and, if so, to know within two or three months how much vision will be restored.
"We're really excited about this," Dr. Eric Pierce, a professor of ophthalmology at Harvard Medical School, who is leading a study that the procedure launched, tells NPR.
"We're helping open, potentially, an era of gene-editing for therapeutic use that could have impact in many aspects of medicine," Pierce says.
The CRISPR gene-editing technique has been revolutionizing scientific research by making it much easier to rewrite the genetic code. It's also raising high hopes of curing many diseases.
Before this step, doctors had only used CRISPR to try to treat a small number of patients who have cancer, or the rare blood disorders sickle cell anemia or beta-thalassemia. While some of the initial results have been promising, it's still too soon to know whether the strategy is working.
In those other cases, doctors removed cells from patients' bodies, edited genes in the cells with CRISPR in the lab and then infused the modified cells back into the volunteers' bodies to either attack their cancer or produce a protein their bodies are missing.
In this new experiment, doctors at the Casey Eye Institute in Portland, Ore., injected (into the eye of a patient who is nearly blind from a condition called Leber congenital amaurosis) microscopic droplets carrying a harmless virus that had been engineered to deliver the instructions to manufacture the CRISPR gene-editing machinery.
Beginning in infancy, the rare genetic condition progressively destroys light-sensing cells in the retina that are necessary for vision. Vision impairment with LCA varies widely, but most patients are legally blind and are only able to differentiate between light and dark or perhaps to detect movement.
"The majority of people affected by this disease have the most severe end of the spectrum, in terms of how poor their vision is," Pierce says. "They're functionally blind."
The goal is that once the virus carrying the CRISPR instructions has been infused into the eye, the gene-editing tool will slice out the genetic defect that caused the blindness. That would, the researchers hope, restore production of a crucial protein and prevent the death of cells in the retina, as well as revive other cells — enabling patients to regain at least some vision.
"It's the first time the CRISPR gene-editing is used directly in a patient," Pierce says. "We're really optimistic that this has a good chance of being effective."
The study is being sponsored by Editas Medicine, of Cambridge, Mass., and Allergan, based in Dublin. It will eventually involve a total of 18 patients, including some as young as ages 3 to 17, who will receive three different doses.
"We're very excited about this. This is the first time we're doing editing inside the body," says Charles Albright, the chief scientific officer at Editas.
"We believe that the ability to edit inside the body is going to open entire new areas of medicine and lead to a whole new class of therapies for diseases that are not treatable any other way," Albright says.
Francis Collins, director of the National Institutes of Health, calls the advance "a significant moment."
"All of us dream that a time might be coming where we could apply this approach for thousands of diseases," Collins tells NPR. "This is the first time that's being tried in a human being. And it gives us hope that we could extend that to lots of other diseases — if it works and if it's safe."
Pierce, Albright and others stressed that only one patient has been treated so far and that the study, still at a very early stage, is designed primarily to determine whether injecting the gene-editing tool directly into the eye is safe.
To that end, the researchers are starting with lowest dose and the oldest patients, who have already suffered extensive damage to their vision. And doctors are only treating one eye in each patient. All of those steps are being taken in case the treatment somehow backfires, causing more damage instead of being helpful.
"CRISPR has never been used directly inside a patient before," Pierce says. "We want to make sure we're doing it right."
Still, he says, if the underlying defect can be repaired in this patient and others with advanced damage, "we have the potential to restore vision to people who never had normal vision before. It would indeed be amazing."
The study involves a form of Leber congenital amaurosis known as Type 10, which is caused by a defect in the CEP290 gene.
If the approach appears to be safe and effective, the researchers will start treating younger patients.
"We believe children have the potential to have the most benefit from their therapy, because we know their visual pathways are still intact," Albright explains.
The procedure, which takes about an hour to perform, involves making tiny incisions that enable access to the back of the eye. That allows a surgeon to inject three droplets of fluid containing billions of copies of the virus that has been engineered to carry the CRISPR gene-editing instructions under the retina.
The idea is that once there, the CRISPR editing elements would snip out the mutation that causes a defect in CEP290. The hope is that this would be a one-time treatment that would correct vision for a lifetime.
If it works, the volunteers in the study might be able to have the procedure repeated on the other eye later.
"If we can do this safely, that opens the possibility to treat many other diseases where it's not possible to remove the cells from the body and do the treatment outside," Pierce says.
The list of such conditions might include some brain disorders, such Huntington's disease and inherited forms of dementia, as well as muscle diseases, such as muscular dystrophy and myotonic dystrophy, according to Pierce and Albright.
"Inherited retinal diseases are a good choice in terms of gene-based therapies," says Artur Cideciyan, a professor of ophthalmology at the University of Pennsylvania, given that the retina is accessible from outside the body
But Cideciyan cautions that other approaches for these conditions are also showing promise, and it remains unclear which will turn out to be the best.
"The gene-editing approach is hypothesized to be a 'forever fix,' " he says. "However, that's not known. And the data will have to be evaluated to see the durability of that. We'll have to see what happens."